Geldanamycin ≥98 %

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Prix
Details
1 mg
€90,20 Sans les taxes
€109,14 Taxes incluses
Variant1 mg
CAS30562-34-6
Code de l'articleHN71.1
Livraison3-4 days
5 mg
€220,13 Sans les taxes
€266,36 Taxes incluses
Variant5 mg
CAS30562-34-6
Code de l'articleHN71.2
Livraison3-4 days
10 mg
€321,72 Sans les taxes
€389,28 Taxes incluses
Variant10 mg
CAS30562-34-6
Code de l'articleHN71.3
Livraison3-4 days
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Informations
Empirical formula C29H40N2O9
Molar mass (M) 560,64 g/mol
Melting point (mp) 275 °C
Storage temp. -20 °C
Transport temp. ambient temp.
WGK 1
CAS No. [30562-34-6]
 
HSP90 inhibitor, tyrosine kinase inhibitor. Benzoquinone ansamycin antibiotic.
Stock solution: 1000x in DMSO or methanol. Storage of stock solution at -20 °C, max. 2 weeks at 4 °C.
Photo sensitive! Store protected from light.
 

Geldanamycin arrests cells in G2 phase, thus interfering with angiogenesis and oncogenesis. The specific binding of geldanamycin to heat shock protein 90 (HSP90) and its ER homologue GP96 leads to inhibition of the chaperone, results in degradation of HSP90 substrates and, subsequently, to deregulation of central cell mechanisms - cell cycle, cell proliferation, apoptosis/cell vitality.

Due to its antitumor potential it may be used as antibiotic against several eucaryotic carcinogenic cell lines. Additionally, geldanamycin is used as inhibitor of tyrosin-kinase and during analysis of several other physiological regulatory mechanisms.

 
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Working concentration: 1-10 µg/ml.
Photo sensitive! Store protected from light.

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